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Randomized Comparison of the Clinical Outcome of Single vs Multiple Arterial Grafts

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ROMA is a prospective event-driven un-blinded randomized multicenter clinical trial. Patients will be randomized to a single arterial graft (SAG) or multiple arterial grafts (MAG). All patients will receive a single internal thoracic artery (ITA) to the left anterior descending coronary artery (LAD). In the Multiple Arterial Graft group, the major vessel to the lateral wall will be grafted with a radial or a second ITA.  The primary outcome will be a composite of death from any cause, any stroke, post-discharge myocardial infarction and/or repeat revascularization. The secondary outcome will be all-cause mortality. The sample size is estimated at 4300 patients.

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